Diabetes Newsletter

Spring 2012

Both type 1 and type 2 diabetes can be treated and managed with healthy eating, physical activity, and taking medications such as insulin to control blood glucose levels. Yale is also conducting research to develop new treatments as well as prevent diabetes in those at risk.

Why Research Matters


In 1979 Dr. Robert Sherwin and Dr. William Tamborlane developed the insulin pump to treat type 1 diabetes. Today it’s used by more than 350,000 patients. Without volunteers like the children and their families who were willing to participate in clinical research, this groundbreaking discovery would not have been possible.


Tips for Controlling Diabetes


When you take care of your diabetes, you’ll feel better. You’ll reduce your risk for problems with your kidneys, eyes, nerves, feet and legs, and teeth. You’ll also lower your risk for a heart attack or a stroke. Your doctor may prescribe medication, but you can also take care of your diabetes by being physically active and following a healthy meal plan.


Research to Treat and Prevent Type 1 Diabetes


When Hannah Rosenfield was diagnosed with Type 1 diabetes at age 10, her mother Amy immediately looked beyond the standard treatment for something that might benefit her daughter long term.


Understanding the Root of Type 2 Diabetes


Dr. Gerald Shulman is working to uncover what happens in cells that leads to insulin resistance, which is at the core of type 2 diabetes. His research is pointing to new drug targets as well as exercise and dietary strategies that may lead to the reversal of insulin resistance and the prevention of type 2 diabetes.


Upcoming Diabetes Trial

A study comparing the effectiveness of three different classes of medications in patients already taking Metformin for Type 2 diabetes. Please check back in November for details.

Diabetes & Related Research Trials

A Phase II Trial to Examine the Effect of Subcutaneous Exenatide (Bydureon®) on Glucose Control in Patients with Type I Diabetes
Disease/Condition: Type 1 Diabetes
Principal Investigator: Kevan Herold
Effect of a Medium Chain Triglyceride Supplemented Diet on Cognitive Function and Brain Activation in Type 1 Diabetes.
Disease/Condition: Hypo-unawareness | Type 1 Diabetes
Principal Investigator: Robert Sherwin
Effect of Formoterol on the Counterregulatory Hormonal Response to Hypoglycemia in Type 1 Diabetes.
Disease/Condition: Type 1 Diabetes
Principal Investigator: Robert Sherwin
Effect of Naltrexone on Counterregulatory Mechanisms in Hypoglycemia
Disease/Condition: Hypoglycemia
Principal Investigator: Robert Sherwin
Glycemic Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE Study)
Disease/Condition: Diabetes Mellitus Type 2
Principal Investigator: William Tamborlane
Investigation Into Effects Upon Counterregulatory Responses to Hypoglycemia During Intensive Treatment of T1DM
Disease/Condition: Hypoglycemia | Type 1 Diabetes
Principal Investigator: Robert Sherwin
Natural History Study of the Development of Type 1 Diabetes
Disease/Condition: Diabetes Mellitus, Type 1
Principal Investigator: Kevan Herold
Oral Insulin for Prevention of Diabetes in Relatives at Risk for Type 1 Diabetes Mellitus
Disease/Condition: Diabetes Mellitus, Type 1
Principal Investigator: Kevan Herold
Prevalence of Carbohydrate Intolerance in Lean and Obese Children
Disease/Condition: Acanthosis Nigricans | Diabetes | Glucose Intolerance | Obesity
Principal Investigator: Sonia Caprio
Stress Management Among Latinos With Type 2 Diabetes
Disease/Condition: Diabetes Mellitus, Type 2
Principal Investigator: Rafael Pérez-Escamilla, Ph.D.
Study to Investigate the Pathophysiology of Type 2 Diabetes in Youth
Disease/Condition: Beta-cell Function | Childhood Obesity | Impaired Glucose Tolerance | Insulin Resistance | Metabolic Syndrome | Pre-Diabetes
Principal Investigator: Sonia Caprio
T1DM Immunotherapy Using CD4+CD127lo/-CD25+ Polyclonal Tregs
Disease/Condition: Type 1 Diabetes Mellitus
Principal Investigator: Kevan Herold
Teplizumab for Prevention of Type 1 Diabetes In Relatives "At-Risk"
Disease/Condition: Autoantibody Positive | High Risk | Impaired Glucose Tolerance | Non-diabetic Relatives at Risk for Type 1 Diabetes
Principal Investigator: Kevan Herold
The Effect of Fatty Liver On Hepatic Gene Expression and Protein Activity
Disease/Condition: Obesity
Principal Investigator: Gerald Shulman
TODAY Genetics Study
Disease/Condition: Type 2 Diabetes
Principal Investigator: Sonia Caprio